CHGB

Entrez Summary: This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009].
UniProt Summary: Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotinamide 2000μM R01 exp50	-2.68
Lapatinib 5μM R01 exp47	-2.47
2-Methoxyestradiol 0.2μM R01 exp40	-2.08
Campthothecin 0.001μM R06 exp270	-2.05
MS023 2μM R03 exp134	-1.93
2-Deoxy-D-glucose 800μM R05 exp214	-1.87
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.86
Ribavirin 10μM R01 exp52	-1.84
Wortmannin 5μM R00 exp38	-1.83
Methotrexate 0.01μM R08 exp501	1.71

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

secretory granule
hormone activity
endoplasmic reticulum lumen
post-translational protein modification
extracellular space