COL28A1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 20μM R00 exp34	-2.06
Nicotinamide Riboside 100μM R03 exp139	1.72
Nocodazole 0.2μM R02 exp64	1.88
Curcumin 6.5μM R06 exp277	2.02
Nocodazole 0.2μM R00 exp24	2.02
Vinblastine 0.015μM R05 exp208	2.15
R-DABN 8μM R03 exp111	2.91
SB743921 0.001μM R05 exp244	2.93
Cycloheximide 0.2μM R00 exp15	3
Rotenone 2μM R00 exp33	3.57

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

extracellular matrix structural constituent conferring tensile strength
collagen trimer
basement membrane
serine-type endopeptidase inhibitor activity
extracellular matrix structural constituent
extracellular matrix
negative regulation of endopeptidase activity
negative regulation of peptidase activity
endoplasmic reticulum lumen
extracellular matrix organization
negative regulation of proteolysis
collagen-containing extracellular matrix
extracellular structure organization
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
regulation of proteolysis
negative regulation of catalytic activity
cell adhesion
biological adhesion
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
extracellular space
extracellular region