CYB561A3

Entrez Summary: N/A
UniProt Summary: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Artemisinin 50μM R08 exp450	-2.79
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.59
CoCl2 18μM R07 exp346	-2.4
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.36
RK-33 8μM R08 exp518	-2.22
Bafilomycin-A1 0.009μM R08 exp454	-2.12
GSK-J4 1.5μM R08 exp441	-1.95
Hydroxyurea 100μM R07 exp329	-1.83
PNU96415E 10μM R03 exp145	1.71
Amiloride 100μM R08 exp447	1.72
Chloramphenicol 2μM R00 exp12	1.72
HMS-I2 5μM R06 exp287	1.77
CCCP 1μM R00 exp11	1.78
ABT-702 5μM R07 exp318	1.81
VHL-ligand-1 20μM R07 exp421	1.83
Zebularine 20μM R07 exp423	1.89
Celastrol 0.12μM R05 exp225	1.93
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	2.01
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	2.02
Epigallocatechin gallate 20μM R05 exp230	2.41
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	3.09

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

late endosome membrane
oxidoreductase activity
lysosomal membrane
oxidation-reduction process