DBH

Entrez Summary: The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017].
UniProt Summary: Conversion of dopamine to noradrenaline. {ECO:0000269|PubMed:27148966, ECO:0000269|PubMed:3443096, ECO:0000269|PubMed:7961964, ECO:0000269|PubMed:8546710}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
IU1-47 25μM R04 exp182	-2.15
Golgicide-A 2μM R03 exp121	-2.08
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.9
VHL-ligand-1 20μM R07 exp421	-1.89
FBS-Wisent 0.1 R07 exp426	-1.84
Vinblastine 0.002μM R01 exp60	-1.72
TRAIL 5ng/ml R00 exp35	1.76
TNF-alpha 44ng/ml R08 exp533	1.77
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.81
Citral 50μM R06 exp274	1.86
Dynasore 7μM R08 exp436	1.89
Thioridazine 5μM R08 exp530	1.9
ABT-702 0.1μM R06 exp260	2.08

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

chromaffin granule lumen
homoiothermy
octopamine biosynthetic process
dopamine beta-monooxygenase activity
octopamine metabolic process
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
chromaffin granule membrane
norepinephrine biosynthetic process
ethanolamine-containing compound metabolic process
dopamine catabolic process
catechol-containing compound catabolic process
catecholamine catabolic process
behavioral response to ethanol
phenol-containing compound catabolic process
norepinephrine metabolic process
parental behavior
maternal behavior
catechol-containing compound biosynthetic process
catecholamine biosynthetic process
L-ascorbic acid binding
cellular biogenic amine biosynthetic process
amine biosynthetic process
dopamine metabolic process
reproductive behavior
temperature homeostasis
response to pain
positive regulation of vasoconstriction
response to amphetamine
blood vessel remodeling
fear response
phenol-containing compound biosynthetic process
transport vesicle membrane
neurotransmitter biosynthetic process
catecholamine metabolic process
catechol-containing compound metabolic process
catalytic activity
response to amine
visual learning
response to bronchodilator
visual behavior