DIEXF

Entrez Summary: N/A
UniProt Summary: Regulates the p53 pathway to control the expansion growth of digestive organs. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mitomycin-C 0.06μM R08 exp503	-1.84
Temozolomide 200μM R04 exp189	1.7
BI-2536 0.0042μM R03 exp95	1.71
Metformin 100 to 150μM on day4 R04 exp170	1.76
NFN1 0.4μM R03 exp99	1.79
proTAME 5μM R04 exp187	1.84
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.94
Beta-Estradiol 0.55μM R07 exp425	1.97
Isoniazid 100μM R08 exp494	2.03
Ibrutinib 10μM R08 exp442	2.07
A-196 10μM R03 exp114	2.09
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.99

Global Fraction of Cell Lines Where Essential: 16/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	4/75
lymphocyte	0/16
ovary	3/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

U3 snoRNA binding
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
rRNA binding
positive regulation of embryonic development
small-subunit processome
maturation of SSU-rRNA
protein destabilization
ribosomal small subunit biogenesis
regulation of embryonic development
rRNA processing
rRNA metabolic process
regulation of protein stability
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
protein catabolic process
nucleolus
RNA processing
macromolecule catabolic process
organonitrogen compound catabolic process
positive regulation of developmental process
RNA binding
RNA metabolic process
positive regulation of multicellular organismal process
organic substance catabolic process
gene expression