ECD

Gene Information

Official Symbol: ECD
Official Name: ecdysoneless cell cycle regulator
Aliases and Previous Symbols: N/A
Entrez ID: 11319
UniProt: O95905
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). {ECO:0000269|PubMed:16849563, ECO:0000269|PubMed:19640839, ECO:0000269|PubMed:19919181, ECO:0000269|PubMed:23880345, ECO:0000269|PubMed:26711270, ECO:0000305|PubMed:24722212, ECO:0000305|PubMed:9928932}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SB743921 0.001μM R05 exp244	-1.81
Rifampicin 10μM R00 exp32	1.88
2-Methoxyestradiol 0.2μM R01 exp40	1.9
Wortmannin 5μM R00 exp38	1.9
Doxycycline 10μM R00 exp18	1.96
Cycloheximide 0.2μM R00 exp15	1.99
DABN 2μM R00 exp16	2.31
Losmapimod 1μM R07 exp376	2.37
5-Fluorouracil 2μM R00 exp1	2.5
Senexin-A 25μM R07 exp400	2.77

Global Fraction of Cell Lines Where Essential: 666/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	24/28
blood	27/28
bone	25/25
breast	30/33
central nervous system	50/56
cervix	4/4
colorectal	17/17
esophagus	10/13
fibroblast	1/1
gastric	14/15
kidney	19/21
liver	15/20
lung	71/75
lymphocyte	13/14
ovary	24/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	17/22
urinary tract	23/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 323
Expression level (log2 read counts): 5.74

Expression Distribution

histone acetyltransferase binding
regulation of glycolytic process
regulation of carbohydrate catabolic process
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
regulation of ATP metabolic process
regulation of G1/S transition of mitotic cell cycle
regulation of generation of precursor metabolites and energy
regulation of cell cycle G1/S phase transition
regulation of carbohydrate metabolic process
transcription coactivator activity
RNA splicing
regulation of mitotic cell cycle phase transition
regulation of small molecule metabolic process
regulation of cell cycle phase transition
mRNA processing
transcription by RNA polymerase II
cell population proliferation
regulation of mitotic cell cycle
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
regulation of cell cycle process
RNA processing
regulation of catabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
positive regulation of transcription by RNA polymerase II
organic cyclic compound biosynthetic process
positive regulation of transcription, DNA-templated
regulation of phosphorylation
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process