EHMT2
Gene Information
- Official Symbol: EHMT2
- Official Name: euchromatic histone lysine methyltransferase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 10919
- UniProt: Q96KQ7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ank 2 |
| Ank |
| SET |
| Pre-SET |
GO Terms
| histone methyltransferase activity (H3-K27 specific) |
| histone methyltransferase activity (H3-K9 specific) |
| histone H3-K27 methylation |
| peptidyl-lysine dimethylation |
| C2H2 zinc finger domain binding |
| histone H3-K9 methylation |
| histone-lysine N-methyltransferase activity |
| histone H3-K9 modification |
| protein-lysine N-methyltransferase activity |
| negative regulation of G0 to G1 transition |
| regulation of G0 to G1 transition |
| DNA methylation |
| DNA alkylation |
| promoter-specific chromatin binding |
| DNA methylation or demethylation |
| p53 binding |
| histone lysine methylation |
| DNA modification |
| peptidyl-lysine methylation |
| histone methylation |
| regulation of DNA replication |
| protein methylation |
| protein alkylation |
| cellular response to starvation |
| regulation of signal transduction by p53 class mediator |
| response to starvation |
| cellular response to nutrient levels |
| nuclear chromatin |
| macromolecule methylation |
| cellular response to extracellular stimulus |
| methylation |
| peptidyl-lysine modification |
| negative regulation of cell cycle process |
| cellular response to external stimulus |
| histone modification |
| covalent chromatin modification |
| nuclear speck |
| response to nutrient levels |
| response to extracellular stimulus |
| negative regulation of cell cycle |
| chromatin organization |
| DNA metabolic process |
| regulation of cell cycle process |
| zinc ion binding |
| negative regulation of transcription by RNA polymerase II |
| peptidyl-amino acid modification |
| chromosome organization |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| cellular response to stress |
| negative regulation of gene expression |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BML-284 0.09μM R08 exp460 | 1.88 |
| UM131593 0.2μM R03 exp106 | 3.29 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1430
- Expression level (log2 read counts): 7.18
Expression Distribution
EHMT2 Expression in NALM6 Cells: 7.18
