EIF1

Entrez Summary: N/A
UniProt Summary: Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 120/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	3/28
bone	4/26
breast	10/33
central nervous system	7/56
cervix	0/4
colorectal	3/17
esophagus	0/13
fibroblast	0/1
gastric	4/16
kidney	7/21
liver	4/20
lung	7/75
lymphocyte	1/16
ovary	5/26
pancreas	3/24
peripheral nervous system	8/16
plasma cell	1/15
prostate	0/1
skin	5/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	5/29
uterus	0/5

Expression Distribution

ribosomal small subunit binding
eukaryotic 43S preinitiation complex
dosage compensation by inactivation of X chromosome
dosage compensation
translation factor activity, RNA binding
translation initiation factor activity
regulation of translational initiation
translational initiation
regulation of gene expression, epigenetic
regulation of translation
translation
regulation of cellular amide metabolic process
peptide biosynthetic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
RNA binding
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression