GATAD2B

Entrez Summary: This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with cognitive disability. [provided by RefSeq, Jun 2016].
UniProt Summary: Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development. {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 50ng/ml R00 exp36	-2.22
Nicotinamide 1000μM R03 exp101	-2.17
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.82
TRAIL 5ng/ml R00 exp35	-1.74
A-769662 20μM R07 exp331	-1.73
Hippuristanol 0.12μM R08 exp488	1.81
Parthenolide 2.5μM R05 exp238	1.87
THZ1 0.06μM R08 exp531	1.94
CCT251545 20μM R07 exp326	1.95
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.04
QNZ 0.01μM R08 exp439	2.15
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.29
Cannabidiol 20μM R08 exp466	2.64

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

NuRD complex
nucleosomal DNA binding
ATP-dependent chromatin remodeling
RNA polymerase II distal enhancer sequence-specific DNA binding
chromatin remodeling
nuclear chromatin
nuclear speck
RNA polymerase II proximal promoter sequence-specific DNA binding
protein-containing complex
chromatin organization
zinc ion binding
negative regulation of transcription by RNA polymerase II
chromosome organization
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression