IFNAR2

Entrez Summary: The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950). {ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:11682488, ECO:0000269|PubMed:12105218, ECO:0000269|PubMed:26424569, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bisphenol A 100μM R06 exp269	-2.27
RK-33 8μM R08 exp518	-2.01
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.74
SGC0649 7μM R03 exp150	1.76
Arsenic trioxide 60μM R08 exp449	1.81
WNT3A 44ng/ml R08 exp537	1.82
Resveratrol 16μM R03 exp147	1.85
PNU96415E 10μM R03 exp145	2.2

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Tissue fac
Interfer-bind

type I interferon receptor activity
response to interferon-alpha
response to interferon-beta
regulation of type I interferon-mediated signaling pathway
receptor signaling pathway via JAK-STAT
receptor signaling pathway via STAT
cytokine receptor activity
cellular response to type I interferon
type I interferon signaling pathway
response to type I interferon
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
defense response to virus
response to virus
regulation of innate immune response
protein kinase binding
regulation of response to biotic stimulus
cytokine-mediated signaling pathway
regulation of defense response
innate immune response
regulation of multi-organism process
defense response to other organism
cellular response to cytokine stimulus
immune effector process
regulation of response to external stimulus
response to cytokine
regulation of immune response
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
integral component of plasma membrane
regulation of response to stress
regulation of immune system process
immune response
extracellular region