LRP10

Entrez Summary: This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vincristine 0.0005μM R04 exp190	-2.61
DABN 20μM R00 exp17	-2.59
LB-100 2μM R05 exp210	-2.43
MLN-4924 0.2μM R00 exp21	-2.31
Rifampicin 1μM R00 exp31	-2.1
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.04
CCT251545 20μM R07 exp326	-1.86
TRAIL 5ng/ml R00 exp35	-1.84
UMK57 1μM R01 exp59	-1.77
A-366 10μM R03 exp115	-1.76
Cerivastatin 0.15μM R05 exp226	-1.76
Nocodazole 0.2μM R00 exp24	-1.75
Vinblastine 0.2μM R03 exp108	-1.75
Fluvastatin 2.2μM R06 exp282	-1.72
Nifurtimox 1μM R03 exp141	-1.7
Thalidomide 20μM R07 exp406	1.72
NN-Diethyl-meta-toluamide 100μM R05 exp237	2.39
Vemurafenib 6.6μM R08 exp434	2.61

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ldl recept a
CUB

low-density lipoprotein particle receptor activity
clathrin-coated pit
inner ear development
ear development
lipid transport
lipid localization
sensory organ development
endocytosis
import into cell
lipid metabolic process
vesicle-mediated transport
membrane