MCF2L

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BVD-523 15μM R02 exp67	-1.9
B02 10μM R08 exp453	1.83
Dimethyloxaloylglycine 11μM R07 exp314	1.86
NFN1 0.1μM R01 exp49	2.15

Rho guanyl-nucleotide exchange factor activity
endomembrane system
phosphatidylinositol binding
regulation of Rho protein signal transduction
regulation of Ras protein signal transduction
regulation of small GTPase mediated signal transduction
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
G protein-coupled receptor signaling pathway
regulation of apoptotic process
regulation of programmed cell death
extracellular space
regulation of cell death
intracellular signal transduction
regulation of intracellular signal transduction