MGAT1

Official Symbol: MGAT1
Official Name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Aliases and Previous Symbols: N/A
Entrez ID: 4245
UniProt: P26572
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Chloroquine 32μM R08 exp470	-2.34
Wortmannin 5μM R00 exp38	-2.12
Vemurafenib 6.6μM R02 exp89	-2.07
Vemurafenib 6.6μM R08 exp434	-2
FTY720 3μM R08 exp483	-1.84
Azithromycin 100μM R08 exp452	-1.78
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.72
Nicotinamide 2000μM R01 exp50	-1.71
Radicicol 0.16μM R05 exp242	1.76
3-Bromopyruvate 7μM R04 exp175	2.32
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.75
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	3.08
Tunicamycin 0.04μM R07 exp418	3.84

Global Fraction of Cell Lines Where Essential: 14/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	3/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
B3GNT2	0.495
MAPKAPK5	0.44

alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
UDP-N-acetylglucosamine catabolic process
nucleotide-sugar catabolic process
amino sugar catabolic process
UDP-N-acetylglucosamine metabolic process
acetylglucosaminyltransferase activity
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
nucleotide-sugar metabolic process
amino sugar metabolic process
nucleobase-containing small molecule catabolic process
extracellular vesicle
manganese ion binding
protein N-linked glycosylation
carbohydrate derivative catabolic process
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
nucleobase-containing compound catabolic process
in utero embryonic development
glycoprotein metabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
Golgi membrane
carbohydrate derivative biosynthetic process
chordate embryonic development
embryo development ending in birth or egg hatching
peptidyl-amino acid modification
embryo development
Golgi apparatus
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process