MSL1

Entrez Summary: N/A
UniProt Summary: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. {ECO:0000269|PubMed:16227571, ECO:0000269|PubMed:21726816, ECO:0000269|PubMed:22547026}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ETC-159 50μM R08 exp480	-2.59
I-BRD9 4μM R07 exp365	-2.43
NMS-873 0.07μM R07 exp380	-2.39
MLN-4924 0.2μM R00 exp21	-2.35
Amiloride 100μM R08 exp447	-2.11
Olaparib 4μM R08 exp512	-1.97
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.96
TNF-alpha 44ng/ml R08 exp533	-1.95
YM155 0.001μM R08 exp432	-1.94
3-Bromopyruvate 7μM R04 exp175	-1.92
Hippuristanol 0.12μM R08 exp488	-1.88
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.87
Erlotinib 10μM R05 exp216	-1.84
Ethanol 0.01 R05 exp234	-1.77
Dynasore 10μM R04 exp180	-1.72
Radicicol 0.16μM R05 exp242	-1.71
Quercetin 20μM R08 exp517	-1.7
CoCl2 18μM R07 exp346	2.54

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

MSL complex
histone H4-K16 acetylation
histone H4 acetylation
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
protein acylation
peptidyl-lysine modification
histone modification
covalent chromatin modification
chromatin binding
chromatin organization
peptidyl-amino acid modification
chromosome organization