NOP14

Entrez Summary: N/A
UniProt Summary: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tanespimycin 14μM R08 exp527	-1.97
AICAR 240μM R03 exp116	-1.73
UM0131023 0.05μM R05 exp248	1.74
Fas-L 44ng/ml R08 exp482	1.78
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.92
BH1 1μM R04 exp169	1.99
NN-Diethyl-meta-toluamide 100μM R05 exp237	2.18

Global Fraction of Cell Lines Where Essential: 455/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	10/28
blood	17/28
bone	14/26
breast	23/33
central nervous system	37/56
cervix	2/4
colorectal	12/17
esophagus	9/13
fibroblast	0/1
gastric	11/16
kidney	12/21
liver	7/20
lung	49/75
lymphocyte	10/16
ovary	16/26
pancreas	13/24
peripheral nervous system	13/16
plasma cell	9/15
prostate	0/1
skin	14/24
soft tissue	7/9
thyroid	2/2
upper aerodigestive	14/22
urinary tract	18/29
uterus	1/5

Expression Distribution

Noc4p-Nop14p complex
rRNA 5-end processing
endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
90S preribosome
endonucleolytic cleavage involved in rRNA processing
endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
snoRNA binding
ncRNA 5-end processing
RNA 5-end processing
cleavage involved in rRNA processing
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
maturation of 5.8S rRNA
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
small-subunit processome
maturation of SSU-rRNA
ribosomal small subunit biogenesis
RNA phosphodiester bond hydrolysis, endonucleolytic
RNA phosphodiester bond hydrolysis
rRNA processing
rRNA metabolic process
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
enzyme binding
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
membrane
gene expression