PARP3

Gene Information

Official Symbol: PARP3
Official Name: poly(ADP-ribose) polymerase family member 3
Aliases and Previous Symbols: N/A
Entrez ID: 10039
UniProt: Q9Y6F1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. {ECO:0000269|PubMed:16924674}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tanespimycin 14μM R08 exp527	-1.9
BN82002 4μM R07 exp340	1.72
Cincreasin 100μM R08 exp473	1.75
Glyphosate 1000μM R06 exp283	1.91
Bafilomycin-A1 0.009μM R08 exp454	2
GSK591 2.6μM R03 exp128	2.18
proTAME 5μM R04 exp187	2.48

Gene	Correlation
GOLGA8O	0.483
TCEB3C	0.463
VASN	0.462
TCEB3CL	0.453
XYLT2	0.452
PSMB4	0.445
KRT78	0.441
CEP192	0.441
MT1E	0.435
POLE	0.429
NPIPB5	0.428
RPS2	0.426
OR11H6	0.424
CHD4	0.424
IK	0.423
GOLGA6L3	0.419
OR10G3	0.418
RPL37A	0.418
PAN3	0.415
NUPL1	0.414
AQR	0.413
NOP16	0.412
RFFL	0.409
ORC1	0.407
TCEB3CL2	0.407
DTL	0.406
TWISTNB	0.404
HIST2H3C	0.404
COL2A1	0.404
HIST2H3A	0.404
AAMP	0.402
GOLGA6L4	0.401
NUP160	0.4

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2400
Expression level (log2 read counts): 3.61

Expression Distribution

WGR
PARP reg
PARP

negative regulation of telomerase RNA reverse transcriptase activity
regulation of telomerase RNA reverse transcriptase activity
DNA ADP-ribosylation
protein localization to site of double-strand break
NAD DNA ADP-ribosyltransferase activity
negative regulation of isotype switching
positive regulation of DNA ligation
regulation of DNA ligation
protein poly-ADP-ribosylation
negative regulation of immunoglobulin mediated immune response
negative regulation of B cell mediated immunity
protein mono-ADP-ribosylation
negative regulation of immunoglobulin production
protein auto-ADP-ribosylation
negative regulation of telomerase activity
positive regulation of double-strand break repair via nonhomologous end joining
protein ADP-ribosylase activity
regulation of double-strand break repair via nonhomologous end joining
NAD+ ADP-ribosyltransferase activity
protein ADP-ribosylation
negative regulation of B cell activation
positive regulation of double-strand break repair
regulation of isotype switching
negative regulation of production of molecular mediator of immune response
negative regulation of lymphocyte mediated immunity
regulation of mitotic spindle organization
negative regulation of DNA biosynthetic process
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of spindle organization
negative regulation of adaptive immune response
catalytic activity
negative regulation of DNA recombination
negative regulation of leukocyte mediated immunity
regulation of B cell mediated immunity
regulation of immunoglobulin mediated immune response
regulation of telomerase activity
site of double-strand break
protein localization to chromosome
regulation of immunoglobulin production
positive regulation of DNA repair