PDCL

Entrez Summary: N/A
UniProt Summary: Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
I-BRD9 4μM R07 exp365	-2.2
Cabazitaxel 0.001μM R05 exp223	-2.01
Curcumin 6.5μM R06 exp277	-1.97
Erlotinib 10μM R05 exp216	1.7
Menadione 5μM R06 exp292	1.78
LY2090314 0.003μM R08 exp500 no dilution day6	1.86
Nicotine 3000μM R08 exp510	1.89
LY2090314 0.003μM R08 exp499	1.93
Cerivastatin 0.15μM R05 exp226	1.94
MS023 7μM R03 exp135	1.98
Benzoate 10000μM R08 exp455	2.01
Ethanol 0.01 R05 exp234	2.04
Etoposide 0.1μM R05 exp198	2.21
MS023 2μM R03 exp134	2.7
Hippuristanol 0.12μM R08 exp489 no dilution day6	3.11
Hippuristanol 0.12μM R08 exp488	3.28
Arsenate 40μM R06 exp264	3.29

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

heterotrimeric G-protein complex assembly
regulation of protein refolding
negative regulation of protein refolding
negative regulation of protein folding
regulation of protein folding
positive regulation of smoothened signaling pathway
regulation of smoothened signaling pathway
regulation of G protein-coupled receptor signaling pathway
cilium
visual perception
sensory perception of light stimulus
protein folding
protein-containing complex binding
sensory perception
cell projection organization
nervous system process
protein-containing complex assembly
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
protein-containing complex subunit organization
system process