PES1

Entrez Summary: N/A
UniProt Summary: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03028, ECO:0000269|PubMed:16738141, ECO:0000269|PubMed:17189298, ECO:0000269|PubMed:17353269}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cytochalasin-B 5μM R07 exp349	-1.72
AICAR 240μM R05 exp211	-1.71
HMS-I2 1μM R06 exp286	1.72
A-395N 10μM R05 exp219	1.76
RS-1 10μM R08 exp519	1.78
Glyphosate 1000μM R06 exp283	1.82
SGC0946 7μM R03 exp151	1.87
TNF-alpha 44ng/ml R08 exp533	1.91
CCT251545 0.2μM R06 exp271	1.94
Cadmium 60μM R08 exp462	1.99
THZ531 0.11 to 0.175μM on day4 R07 exp413	2
Disulfiram 4.3μM R06 exp281	2.01
SB202190 10μM R03 exp148	2.01
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.03
Sucrose 20000μM R06 exp298	2.13
Radicicol 0.16μM R05 exp242	2.19
MKC9989 10μM R03 exp133	2.25
WNT3A 44ng/ml R08 exp537	2.25
Pomalidomide 20μM R07 exp391	2.28
Ethanol 0.003 R08 exp437	2.46

Global Fraction of Cell Lines Where Essential: 413/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	13/28
blood	10/28
bone	14/26
breast	21/33
central nervous system	38/56
cervix	4/4
colorectal	8/17
esophagus	8/13
fibroblast	1/1
gastric	10/16
kidney	13/21
liver	11/20
lung	42/75
lymphocyte	8/16
ovary	17/26
pancreas	11/24
peripheral nervous system	7/16
plasma cell	9/15
prostate	1/1
skin	12/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	8/22
urinary tract	13/29
uterus	4/5

Expression Distribution

BRCT
Pescadillo N

PeBoW complex
nucleolus organization
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
maturation of LSU-rRNA
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
preribosome, large subunit precursor
condensed chromosome
maturation of 5.8S rRNA
ribonucleoprotein complex binding
ribosomal large subunit biogenesis
nucleus organization
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
cell population proliferation
protein localization to organelle
nucleolus
RNA processing
regulation of cell cycle
RNA binding
cellular protein localization
cellular macromolecule localization
RNA metabolic process
membrane
gene expression