PHF6

Entrez Summary: This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by cognitive disability, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms. [provided by RefSeq, Jun 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ribavirin 10 to 15μM on day4 R04 exp160	-1.92
Azithromycin 100μM R08 exp452	-1.86
Nicotinamide Riboside 100μM R03 exp139	-1.85
SGC0946 7μM R03 exp151	-1.85
Temozolomide 200μM R04 exp189	-1.81
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.79
UNC1999 2μM R03 exp155	-1.79
Cerivastatin 0.15μM R05 exp226	-1.75
proTAME 5μM R04 exp187	-1.74
Atovaquone 15μM R08 exp451	1.8
LLY-283 2.6μM R06 exp290	1.8
PU-H71 1μM R08 exp515	1.81
Aminopterin 0.005μM R07 exp335	1.82
Selumetinib 20μM R02 exp81	1.84
Q15 1 to 2μM on day4 R04 exp164	1.86
TRAIL 50ng/ml R00 exp36	1.88
TRAIL 5ng/ml R00 exp35	1.99
A-366 10μM R03 exp115	2.09
SNS-032 15μM R08 exp443	2.17
THZ1 0.06μM R08 exp531	2.18
Lead acetate 2000μM R08 exp497	2.2
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.31
Trametinib 10μM R02 exp83	2.55
Lead acetate 2000μM R08 exp498 no dilution day6	2.59
Hypoxia 5%O2 R04 exp191	2.91

Global Fraction of Cell Lines Where Essential: 0/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/14
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Gene	Correlation
PHIP	0.559
KCTD5	0.403

hatching
organism emergence from protective structure
blastocyst hatching
ribonucleoprotein complex binding
phosphoprotein binding
tubulin binding
scaffold protein binding
condensed chromosome kinetochore
blastocyst development
histone deacetylase binding
histone binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
enzyme binding
in utero embryonic development
sequence-specific DNA binding
chordate embryonic development
embryo development ending in birth or egg hatching
nucleolus
negative regulation of transcription by RNA polymerase II
embryo development
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression