PMPCA

• Official Symbol: PMPCA
• Official Name: peptidase, mitochondrial processing subunit alpha
• Aliases and Previous Symbols: N/A
• Entrez ID: 23203
• UniProt: Q10713
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: The protein encoded by this gene is found in the mitochondrion, where it represents the alpha subunit of a proteolytic heterodimer. This heterodimer is responsible for cleaving the transit peptide from nuclear-encoded mitochondrial proteins. Defects in this gene are a cause of spinocerebellar ataxia, autosomal recessive 2. [provided by RefSeq, Mar 2016].
• UniProt Summary: Cleaves presequences (transit peptides) from mitochondrial protein precursors. {ECO:0000269|PubMed:25808372}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 1419
• Expression level (log2 read counts): 6.89

Expression Distribution

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PMPCA Expression in NALM6 Cells: 6.89