PSMD4

Gene Information

Official Symbol: PSMD4
Official Name: proteasome 26S subunit, non-ATPase 4
Aliases and Previous Symbols: N/A
Entrez ID: 5710
UniProt: P55036
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008].
UniProt Summary: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15826667}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Centrinone 0.5μM R07 exp343	-2.28
Brefeldin A 0.02μM R00 exp8	-2.24
Colchicine 0.009μM R05 exp215	-2.09
Latrunculin-B 10μM R07 exp374	-2
THZ1 0.06μM R08 exp531	-1.97
Cisplatin 0.35μM R06 exp273	-1.94
BVD-523 15μM R02 exp67	-1.92
Olaparib 4μM R08 exp512	-1.89
PU-H71 1μM R08 exp515	-1.89
SGC2043 10μM R03 exp152	-1.85
Lead acetate 2000μM R08 exp498 no dilution day6	-1.81
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.78
UM131593 0.2μM R03 exp106	-1.78
Lead acetate 2000μM R08 exp497	-1.76
Geldanamycin 0.01μM R05 exp235	-1.73
S-trityl-L-cysteine 0.5μM R05 exp243	-1.72
Amiloride 100μM R08 exp447	-1.71
B02 10μM R08 exp453	1.92
YM155 0.001μM R08 exp432	2.1

Global Fraction of Cell Lines Where Essential: 726/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	25/26
breast	33/33
central nervous system	53/56
cervix	4/4
colorectal	16/17
esophagus	12/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	23/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 1756
Expression level (log2 read counts): 6.34

Expression Distribution

proteasome regulatory particle, base subcomplex
proteasome assembly
proteasome accessory complex
polyubiquitin modification-dependent protein binding
proteasome complex
regulation of cellular amino acid metabolic process
regulation of hematopoietic stem cell differentiation
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of transcription from RNA polymerase II promoter in response to hypoxia
antigen processing and presentation of exogenous peptide antigen via MHC class I
regulation of cellular amine metabolic process
NIK/NF-kappaB signaling
anaphase-promoting complex-dependent catabolic process
regulation of hematopoietic progenitor cell differentiation
negative regulation of G2/M transition of mitotic cell cycle
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
interleukin-1-mediated signaling pathway
Wnt signaling pathway, planar cell polarity pathway
antigen processing and presentation of peptide antigen via MHC class I
negative regulation of cell cycle G2/M phase transition
regulation of establishment of planar polarity
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
regulation of stem cell differentiation
tumor necrosis factor-mediated signaling pathway
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
non-canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
regulation of cellular ketone metabolic process
Fc-epsilon receptor signaling pathway
negative regulation of canonical Wnt signaling pathway
cellular response to interleukin-1
T cell receptor signaling pathway
positive regulation of Wnt signaling pathway
antigen processing and presentation of exogenous peptide antigen
regulation of mRNA stability
regulation of morphogenesis of an epithelium
antigen processing and presentation of exogenous antigen
regulation of RNA stability