PSPC1

Gene Information

Official Symbol: PSPC1
Official Name: paraspeckle component 1
Aliases and Previous Symbols: N/A
Entrez ID: 55269
UniProt: Q8WXF1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011].
UniProt Summary: Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. {ECO:0000250|UniProtKB:Q8R326, ECO:0000269|PubMed:22416126, ECO:0000269|PubMed:28712728}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 2μM R00 exp25	-2.75
Wortmannin 5μM R00 exp38	-2.27
NN-Dimethylsphingosine 2.5μM R08 exp508	-2.19
Rapamycin 2μM plus FK-506 5μM R07 exp308	-2.01
Bafilomycin-A1 0.009μM R08 exp454	-1.73
Chloramphenicol 20μM R00 exp13	-1.73
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.9
Bisphenol F 50μM R08 exp457	1.97
3-Bromopyruvate 7μM R04 exp175	2.45

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15571
Expression level (log2 read counts): 6.57

Expression Distribution

RRM 1
NOPS

paraspeckles
E-box binding
transcription regulatory region sequence-specific DNA binding
nuclear matrix
regulation of circadian rhythm
fibrillar center
activation of innate immune response
rhythmic process
positive regulation of innate immune response
positive regulation of response to biotic stimulus
nuclear speck
regulation of innate immune response
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
positive regulation of response to external stimulus
activation of immune response
regulation of defense response
innate immune response
regulation of multi-organism process
positive regulation of immune response
defense response to other organism
regulation of response to external stimulus
regulation of immune response
positive regulation of immune system process
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
response to other organism
response to external biotic stimulus
response to biotic stimulus
negative regulation of RNA metabolic process
defense response
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
regulation of response to stress
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process