SGMS1
Gene Information
- Official Symbol: SGMS1
- Official Name: sphingomyelin synthase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 259230
- UniProt: Q86VZ5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PAP2 |
GO Terms
| ceramide phosphoethanolamine synthase activity |
| ceramide cholinephosphotransferase activity |
| sphingomyelin synthase activity |
| sphingomyelin biosynthetic process |
| Golgi trans cisterna |
| sphingomyelin metabolic process |
| ceramide biosynthetic process |
| integral component of Golgi membrane |
| kinase activity |
| ceramide metabolic process |
| sphingolipid biosynthetic process |
| integral component of endoplasmic reticulum membrane |
| membrane lipid biosynthetic process |
| sphingolipid metabolic process |
| regulation of intrinsic apoptotic signaling pathway |
| cellular response to lipopolysaccharide |
| cellular response to molecule of bacterial origin |
| ammonium ion metabolic process |
| membrane lipid metabolic process |
| cellular response to biotic stimulus |
| cellular response to tumor necrosis factor |
| phospholipid biosynthetic process |
| response to tumor necrosis factor |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| phospholipid metabolic process |
| regulation of apoptotic signaling pathway |
| inflammatory response |
| cellular response to lipid |
| amide biosynthetic process |
| organophosphate biosynthetic process |
| lipid biosynthetic process |
| Golgi membrane |
| response to bacterium |
| cellular amide metabolic process |
| response to lipid |
| organophosphate metabolic process |
| apoptotic process |
| cellular lipid metabolic process |
| cellular response to cytokine stimulus |
| endoplasmic reticulum |
| programmed cell death |
| cellular response to oxygen-containing compound |
| cell death |
| response to cytokine |
| lipid metabolic process |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| integral component of plasma membrane |
| organonitrogen compound biosynthetic process |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| cellular nitrogen compound biosynthetic process |
| regulation of cell death |
| regulation of intracellular signal transduction |
| positive regulation of gene expression |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BH1 1μM R04 exp169 | -4.01 |
| Q15 1 to 2μM on day4 R04 exp164 | -3.43 |
| WYE-354 6μM R02 exp90 | -3.38 |
| Clomiphene 4.4μM R02 exp68 | -3.34 |
| CFI-400945 25μM R08 exp469 | -2.98 |
| Lapatinib 5μM R01 exp47 | -2.28 |
| Bortezomib 0.05μM R00 exp7 | -2.26 |
| Q15 2.7μM R02 exp79 | -2.25 |
| SNS-032 15μM R08 exp443 | -2.03 |
| BS-181 20μM R08 exp461 | -1.96 |
| Vemurafenib 6.6μM R08 exp434 | -1.88 |
| Trimetrexate 0.03μM R08 exp535 | -1.78 |
| Vincristine 0.0005μM R04 exp190 | -1.76 |
| Aminopterin 0.005μM R07 exp335 | 1.88 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7270
- Expression level (log2 read counts): 3.08
Expression Distribution
SGMS1 Expression in NALM6 Cells: 3.08