SSR2

Entrez Summary: N/A
UniProt Summary: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0011500 5μM R05 exp245	-3.02
Heregulin-B 44ng/ml R08 exp486	-1.88
Isonicotinamide 500μM R03 exp129	-1.8
Vemurafenib 6.6μM R02 exp89	-1.79
Thapsigargin 0.005μM R07 exp407	-1.78
TRAIL 5ng/ml R00 exp35	-1.77
BI-6727 0.04μM R03 exp98	1.72
UM0131023 0.05μM R05 exp248	1.8
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.84
Hippuristanol 0.12μM R08 exp488	1.91
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.96
Citral 75μM R06 exp275	2.05
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.05
Vinorelbine 0.001μM R05 exp249	2.1
Rotenone 0.07μM R08 exp431	2.16
Trimetrexate 0.03μM R08 exp535	2.59

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cotranslational protein targeting to membrane
protein targeting to membrane
establishment of protein localization to membrane
protein targeting
in utero embryonic development
protein localization to membrane
chordate embryonic development
embryo development ending in birth or egg hatching
endoplasmic reticulum membrane
embryo development
intracellular protein transport
endoplasmic reticulum
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport