TGFBRAP1

Official Symbol: TGFBRAP1
Official Name: transforming growth factor beta receptor associated protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 9392
UniProt: Q8WUH2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016].
UniProt Summary: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. {ECO:0000269|PubMed:11278302, ECO:0000269|PubMed:9545258}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Bafilomycin-A1 0.009μM R08 exp454	-1.9
Golgicide-A 4μM R03 exp122	-1.75

CORVET complex
endosomal vesicle fusion
transforming growth factor beta receptor binding
SMAD binding
endosome to lysosome transport
vesicle fusion
organelle membrane fusion
organelle fusion
transforming growth factor beta receptor signaling pathway
lysosomal transport
membrane fusion
vacuolar transport
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
transmembrane receptor protein serine/threonine kinase signaling pathway
early endosome
vesicle organization
cellular response to growth factor stimulus
response to growth factor
intracellular membrane-bounded organelle
enzyme linked receptor protein signaling pathway
membrane organization
intracellular protein transport
cellular response to endogenous stimulus
response to endogenous stimulus
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport
membrane