TMEM230

Entrez Summary: This gene encodes a multi-pass transmembrane protein that belongs to the TMEM134/TMEM230 protein family. The encoded protein localizes to secretory and recycling vesicle in the neuron and may be involved in synaptic vesicles trafficking and recycling. Mutations in this gene may be linked to familial Parkinson's disease. [provided by RefSeq, Mar 2017].
UniProt Summary: Involved in trafficking and recycling of synaptic vesicles. {ECO:0000269|PubMed:27270108}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vincristine 0.0005μM R04 exp190	-3.62
BI-D1870 3.15μM R02 exp66	-2.44
LB-100 2μM R05 exp210	-2.42
LB-100 4.1μM R02 exp72	-2.4
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.38
Rapamycin 2μM plus FK-506 5μM R07 exp308	-2.26
Fluvastatin 2.2μM R06 exp282	-2.11
GSK-J4 1.5μM R08 exp441	-2.07
Citral 50μM R06 exp274	-1.97
RS-1 10μM R08 exp519	-1.93
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.89
Artemisinin 50μM R08 exp450	-1.87
Dynasore 10μM R04 exp180	-1.81
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.78
Bortezomib 0.005μM R00 exp6	-1.77
THZ531 0.11μM R07 exp409	-1.76
Ibrutinib 1μM R07 exp372	-1.75
MLN-4924 0.2μM R00 exp21	-1.74
iCRT14 30μM R08 exp492	-1.7
Sulforaphane 9μM R08 exp525	-1.7
Arsenate 40μM R06 exp264	1.72
Vemurafenib 6.6μM R02 exp89	1.73
Momordin-Ic 10μM R08 exp506	2.51
Vemurafenib 6.6μM R08 exp434	2.56

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
ATP8B2	0.484
TMEM30A	0.477

synaptic vesicle transport
synaptic vesicle localization
autophagosome
recycling endosome
synaptic vesicle
late endosome
trans-Golgi network
establishment of vesicle localization
vesicle localization
early endosome
establishment of organelle localization
cell junction
organelle localization
endoplasmic reticulum
establishment of localization in cell