TNFRSF4

Gene Information

Official Symbol: TNFRSF4
Official Name: TNF receptor superfamily member 4
Aliases and Previous Symbols: N/A
Entrez ID: 7293
UniProt: P43489
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. {ECO:0000269|PubMed:7704935}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Selumetinib 20μM R02 exp81	-2.05
UM131593 0.2μM R03 exp106	-2.03
Trametinib 10μM R02 exp83	-2.02
2-Deoxy-D-glucose 800μM R05 exp214	-1.96
S-trityl-L-cysteine 0.5μM R05 exp243	-1.93
BI-2536 0.02μM R03 exp96	-1.91
ETC-159 50μM R08 exp480	-1.89
5-Fluorouracil 2μM R00 exp1	-1.88
Myriocin 25μM R06 exp293	-1.75
D-Fructose 10000μM R06 exp279	1.99

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18526
Expression level (log2 read counts): -5.01

Expression Distribution

tumor necrosis factor-activated receptor activity
positive regulation of immunoglobulin secretion
regulation of immunoglobulin secretion
T cell proliferation
positive regulation of B cell proliferation
positive regulation of immunoglobulin production
regulation of B cell proliferation
regulation of immunoglobulin production
negative regulation of cytokine secretion
virus receptor activity
lymphocyte proliferation
mononuclear cell proliferation
viral entry into host cell
positive regulation of production of molecular mediator of immune response
leukocyte proliferation
entry into host
entry into host cell
tumor necrosis factor-mediated signaling pathway
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
negative regulation of protein secretion
positive regulation of leukocyte proliferation
negative regulation of peptide secretion
regulation of production of molecular mediator of immune response
interaction with host
negative regulation of DNA-binding transcription factor activity
positive regulation of B cell activation
negative regulation of protein transport
negative regulation of establishment of protein localization
viral life cycle
negative regulation of secretion by cell
regulation of cytokine secretion
regulation of B cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
positive regulation of immune effector process
regulation of leukocyte proliferation
negative regulation of secretion
T cell activation
cellular response to tumor necrosis factor