TSR2

Entrez Summary: The protein encoded by this gene appears to repress the transcription of NF-kappaB and may be involved in apoptosis. Defects in this gene are a cause of Diamond-Blackfan anemia. [provided by RefSeq, Oct 2016].
UniProt Summary: May be involved in 20S pre-rRNA processing. {ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 693/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	26/26
bone	26/26
breast	30/30
central nervous system	49/49
cervix	4/4
colorectal	17/17
esophagus	11/11
fibroblast	1/1
gastric	14/14
kidney	18/18
liver	19/19
lung	72/72
lymphocyte	16/16
ovary	25/25
pancreas	22/22
peripheral nervous system	15/15
plasma cell	12/12
prostate	1/1
skin	20/20
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/28
uterus	5/5

Expression Distribution

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
maturation of SSU-rRNA
ribosomal small subunit biogenesis
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
RNA processing
RNA metabolic process
gene expression