YME1L1

Gene Information

Official Symbol: YME1L1
Official Name: YME1 like 1 ATPase
Aliases and Previous Symbols: N/A
Entrez ID: 10730
UniProt: Q96TA2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
UniProt Summary: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26923599, PubMed:27786171). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599). Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (PubMed:22262461). {ECO:0000269|PubMed:18076378, ECO:0000269|PubMed:22262461, ECO:0000269|PubMed:26923599, ECO:0000269|PubMed:27495975, ECO:0000269|PubMed:27786171}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
FK-506 30μM R07 exp359	-1.74
Hypoxia 5%O2 R04 exp191	1.72
Docosahexaenoic-acid 50μM R07 exp356	1.76
Phenformin 20μM R03 exp143	1.79
Menadione 5μM R06 exp292	1.81
Rucaparib 6.5μM R08 exp520	1.82
LY2090314 0.003μM R08 exp499	1.89
Taxol 0.002μM R01 exp54	1.89
Pyronaridine 1μM R06 exp295	1.93
Dorsomorphin 5μM R07 exp357	2.05
UM131593 0.2μM R03 exp106	2.06
MS023 7μM R03 exp135	2.09
Docetaxel 0.002μM R01 exp45	2.15
Talazoparib 0.006μM R06 exp299	2.17
LLY-284 2.6μM R06 exp291	2.2
BML-284 0.09μM R08 exp460	2.21
Quercetin 20μM R08 exp517	2.21
MLN-4924 0.2μM R00 exp21	2.51
Lapatinib 5μM R01 exp47	2.78
HMS-I2 5μM R06 exp287	2.89

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1546
Expression level (log2 read counts): 7.92

Expression Distribution

Peptidase M41
AAA

ATP-dependent peptidase activity
mitochondrial protein catabolic process
mitochondrial protein processing
protein hexamerization
mitochondrial calcium ion transmembrane transport
protein quality control for misfolded or incompletely synthesized proteins
metalloendopeptidase activity
protein processing
calcium ion transmembrane transport
protein maturation
calcium ion transport
nuclear body
divalent metal ion transport
divalent inorganic cation transport
mitochondrial inner membrane
mitochondrion organization
protein complex oligomerization
cell population proliferation
inorganic cation transmembrane transport
proteolysis involved in cellular protein catabolic process
cation transmembrane transport
cellular protein catabolic process
metal ion transport
inorganic ion transmembrane transport
protein catabolic process
cation transport
negative regulation of apoptotic process
negative regulation of programmed cell death
cellular macromolecule catabolic process
ion transmembrane transport
negative regulation of cell death
macromolecule catabolic process
organonitrogen compound catabolic process
mitochondrion
proteolysis
transmembrane transport
ion transport
ATP binding
regulation of apoptotic process
protein-containing complex assembly