ZDHHC17

Entrez Summary: N/A
UniProt Summary: Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). Palmitoylates MPP1 in erythrocytes (PubMed:22496366). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299). {ECO:0000269|PubMed:12393793, ECO:0000269|PubMed:15489887, ECO:0000269|PubMed:15603740, ECO:0000269|PubMed:18794299, ECO:0000269|PubMed:19139280, ECO:0000269|PubMed:22496366, ECO:0000269|PubMed:28757145}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.82
Cyclosporin-A 0.8μM R07 exp347	1.75
Dexamethasone 0.006μM R07 exp351	1.75
Golgicide-A 4μM R03 exp122	1.79
Lead acetate 2000μM R08 exp498 no dilution day6	1.83
VER-155008 3.9μM R06 exp301	1.83
Lead acetate 2000μM R08 exp497	1.89
GSK626616 14μM R08 exp485	1.92
Alpha-Amanitin 0.5μM R00 exp5	2.01
UM0125461 0.74μM R02 exp84	2.04
Q15 2.7μM R02 exp79	2.11
CAY10603 0.55μM R08 exp467	2.17
Vemurafenib 6.6μM R02 exp89	2.23
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.42
TRAIL 50ng/ml R00 exp36	2.42
MK-1775 0.32μM R02 exp75	2.65
Wortmannin 5μM R00 exp38	2.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lipoprotein localization
lipoprotein transport
magnesium ion transmembrane transport
magnesium ion transmembrane transporter activity
magnesium ion transport
palmitoyltransferase activity
Golgi-associated vesicle membrane
protein-cysteine S-palmitoyltransferase activity
protein palmitoylation
aggresome
presynaptic membrane
protein lipidation
lipoprotein biosynthetic process
lipoprotein metabolic process
cytoplasmic vesicle membrane
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein acylation
regulation of I-kappaB kinase/NF-kappaB signaling
divalent metal ion transport
divalent inorganic cation transport
cell junction
inorganic cation transmembrane transport
cation transmembrane transport
Golgi membrane
metal ion transport
inorganic ion transmembrane transport
intracellular membrane-bounded organelle
cation transport
ion transmembrane transport
Golgi apparatus
positive regulation of intracellular signal transduction
identical protein binding
transmembrane transport
ion transport
organonitrogen compound biosynthetic process
protein transport
peptide transport
amide transport
establishment of protein localization
positive regulation of signal transduction