ZDHHC6

Entrez Summary: N/A
UniProt Summary: Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (PubMed:22314232, PubMed:22728137, PubMed:25368151, PubMed:28826475). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (PubMed:22314232). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (PubMed:22728137). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). {ECO:0000269|PubMed:22314232, ECO:0000269|PubMed:22728137, ECO:0000269|PubMed:25368151, ECO:0000269|PubMed:28826475}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bafilomycin-A1 0.009μM R08 exp454	-2.92
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.55
Cadmium 60μM R08 exp462	-1.96
Wiskostatin 3μM R07 exp422	1.84
Aphidicolin 0.04μM R06 exp263	1.85
BI-6727 0.001μM R01 exp42	1.98

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-DHHC
SH3 2

palmitoyltransferase activity
peptidyl-L-cysteine S-palmitoylation
peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
protein-cysteine S-palmitoyltransferase activity
protein palmitoylation
peptidyl-cysteine modification
protein lipidation
lipoprotein biosynthetic process
lipoprotein metabolic process
protein targeting to membrane
protein acylation
establishment of protein localization to membrane
protein targeting
protein localization to membrane
peptidyl-amino acid modification
endoplasmic reticulum membrane
Golgi apparatus
intracellular protein transport
endoplasmic reticulum
organonitrogen compound biosynthetic process
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
establishment of localization in cell
nitrogen compound transport