ZNF292

Entrez Summary: This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017].
UniProt Summary: May be involved in transcriptional regulation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Milciclib 2μM R08 exp502	-2.58
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.58
TIC10 10μM R08 exp532	-2.52
BML-284 0.09μM R08 exp460	-2.28
UM131593 0.2μM R03 exp106	-2.23
JQ1 0.8μM R08 exp435	-2.2
UMK57 1μM R01 exp59	-2
Aphidicolin 0.4μM R08 exp440	-1.93
GSK-J4 1.5μM R08 exp441	-1.85
Cannabidiol 20μM R08 exp466	-1.82
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.78
Hypoxia 5%O2 R04 exp191	1.79
Myriocin 25μM R06 exp293	1.88
MK2206 4μM R08 exp504	1.92
VE-822 0.04μM R06 exp300	2.16
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	3.17

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DNA-binding transcription activator activity, RNA polymerase II-specific
positive regulation of transcription by RNA polymerase II
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process