FNIP1
Gene Information
- Official Symbol: FNIP1
- Official Name: folliculin interacting protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 96459
- UniProt: Q8TF40
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:17028174). May regulate phosphorylation of RPS6KB1 (PubMed:18663353). {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:27353360}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of B cell apoptotic process |
| ATPase inhibitor activity |
| regulation of pro-B cell differentiation |
| regulation of lymphoid progenitor cell differentiation |
| immature B cell differentiation |
| regulation of B cell apoptotic process |
| positive regulation of lymphocyte apoptotic process |
| negative regulation of TORC1 signaling |
| positive regulation of leukocyte apoptotic process |
| TOR signaling |
| regulation of TORC1 signaling |
| negative regulation of TOR signaling |
| regulation of lymphocyte apoptotic process |
| negative regulation of mitochondrion organization |
| regulation of leukocyte apoptotic process |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of hematopoietic progenitor cell differentiation |
| negative regulation of cysteine-type endopeptidase activity |
| regulation of TOR signaling |
| chaperone binding |
| guanyl-nucleotide exchange factor activity |
| positive regulation of peptidyl-serine phosphorylation |
| B cell differentiation |
| regulation of peptidyl-serine phosphorylation |
| cellular response to starvation |
| B cell activation |
| regulation of mitochondrion organization |
| response to starvation |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| cellular response to nutrient levels |
| lymphocyte differentiation |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| positive regulation of protein complex assembly |
| negative regulation of peptidase activity |
| cellular response to extracellular stimulus |
| leukocyte differentiation |
| cellular response to external stimulus |
| negative regulation of proteolysis |
| negative regulation of organelle organization |
| lymphocyte activation |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| regulation of protein complex assembly |
| regulation of hemopoiesis |
| negative regulation of hydrolase activity |
| response to nutrient levels |
| negative regulation of intracellular signal transduction |
| positive regulation of cellular component biogenesis |
| response to extracellular stimulus |
| hemopoiesis |
| hematopoietic or lymphoid organ development |
| positive regulation of apoptotic process |
| immune system development |
| positive regulation of programmed cell death |
| positive regulation of cell death |
| negative regulation of cellular component organization |
| regulation of proteolysis |
| negative regulation of catalytic activity |
| negative regulation of transcription by RNA polymerase II |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| leukocyte activation |
| regulation of cellular component biogenesis |
| negative regulation of cell death |
| positive regulation of protein phosphorylation |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| cell activation |
| negative regulation of protein metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| regulation of organelle organization |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Wortmannin 5μM R00 exp38 | -2.23 |
| KU-0063794 3.8μM R02 exp71 | -1.93 |
| Cidofovir 10μM R07 exp345 | -1.8 |
| VE-822 0.04μM R06 exp300 | -1.73 |
| MS094 2μM R03 exp136 | -1.71 |
| 3-Bromopyruvate 7μM R04 exp175 | 1.88 |
| CR131-b 0.005μM R08 exp474 | 1.98 |
| TRAIL 5ng/ml R00 exp35 | 4.72 |
| TRAIL 50ng/ml R00 exp36 | 4.87 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| FLCN | 0.693 |
| LAMTOR4 | 0.665 |
| LAMTOR2 | 0.659 |
| RRAGA | 0.595 |
| WDR24 | 0.591 |
| MIOS | 0.564 |
| CCNC | 0.527 |
| CASP3 | 0.519 |
| TBC1D5 | 0.507 |
| LAMTOR1 | 0.494 |
| LAMTOR5 | 0.494 |
| LAMTOR3 | 0.479 |
| GABARAP | 0.468 |
| VPS41 | 0.454 |
| LSM12 | 0.448 |
| FBXO11 | 0.434 |
| TNFRSF10B | 0.434 |
| CLK3 | 0.433 |
| EIF4G1 | 0.424 |
| PAX5 | 0.424 |
| FADD | 0.421 |
| SPOP | 0.42 |
| THOC6 | 0.414 |
| WDR59 | 0.413 |
| MED13L | 0.406 |
| KHDRBS1 | 0.406 |
| ZNF217 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2859
- Expression level (log2 read counts): 5.15
Expression Distribution
FNIP1 Expression in NALM6 Cells: 5.15
