KEAP1

Entrez Summary: N/A
UniProt Summary: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. {ECO:0000269|PubMed:14585973, ECO:0000269|PubMed:15379550, ECO:0000269|PubMed:15572695, ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:17046835}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-2.75
Lead acetate 2000μM R08 exp498 no dilution day6	-2.72
Taxol 0.004μM R03 exp103	-2.6
Radicicol 0.16μM R05 exp242	-2.55
Lead acetate 2000μM R08 exp497	-2.4
LY2090314 0.003μM R08 exp499	-2.32
Tozasertib 0.1μM R07 exp414	-2.28
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.26
Sulforaphane 9μM R08 exp526 no dilution day6	-2.25
iCRT14 30μM R08 exp492	-2.2
Thapsigargin 0.005μM R07 exp407	-2.12
AICAR 240μM R03 exp116	-2.09
FK-506 30μM R07 exp359	-2.06
Phenformin 20μM R05 exp212	-1.98
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.93
LJH685 5μM R02 exp73	-1.93
LB-100 4.1μM R02 exp72	-1.92
Cabazitaxel 0.001μM R05 exp223	-1.84
Tenofovir 10μM R07 exp405	-1.83
Dexamethasone 0.006μM R07 exp351	-1.8
Parthenolide 2.5μM R05 exp238	-1.79
Sulforaphane 9μM R08 exp525	-1.79
Apcin 50 to 100μM on day4 R04 exp176	-1.77
LB-100 2μM R05 exp210	-1.77
Golgicide-A 4μM R03 exp122	-1.76
Clomiphene 4.4μM R02 exp68	-1.75
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.74
5-Azacytidine 2μM R07 exp330	-1.71
UM0129480 7μM R02 exp85	-1.7
Dynasore 7μM R08 exp436	1.78
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.78
Epigallocatechin gallate 20μM R05 exp230	1.87
Thimerosal 0.85μM R08 exp529	2.43
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.46
Arsenic trioxide 60μM R08 exp449	4.24

Gene	Correlation
BACH2	0.421

Global Fraction of Cell Lines Where Essential: 26/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	6/33
central nervous system	1/56
cervix	2/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	2/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution