KREMEN1

Entrez Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK343 3μM R03 exp124	-1.75
BI-D1870 2μM R04 exp162	1.7
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.73
DKK1 89ng/ml R08 exp477	1.74
Metformin 100 to 150μM on day4 R04 exp170	1.74
Dimethyloxaloylglycine 11μM R07 exp314	1.75
Nicotine 3000μM R08 exp510	1.78
PNU96415E 10μM R03 exp145	1.79
Alpha-Amanitin 0.5μM R00 exp5	1.84
Chloramphenicol 2μM R00 exp12	1.88
Trametinib 10μM R02 exp83	2.08
Caffeine 2600μM R08 exp463	2.18
NFN1 0.4μM R03 exp99	2.24
Wortmannin 0.5μM R00 exp37	2.6
Rifampicin 10μM R00 exp32	2.65

Gene	Correlation
TRA2B	0.441

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution