SYVN1

Gene Information

Official Symbol: SYVN1
Official Name: synoviolin 1
Aliases and Previous Symbols: N/A
Entrez ID: 84447
UniProt: Q86TM6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011].
UniProt Summary: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity). {ECO:0000250|UniProtKB:Q9DBY1, ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16289116, ECO:0000269|PubMed:16847254, ECO:0000269|PubMed:17059562, ECO:0000269|PubMed:17141218, ECO:0000269|PubMed:17170702, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:26471130}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus CoCl2 18μM R07 exp320	-3.18
MK2206 4μM R08 exp504	-2.1
Nocodazole 0.1μM R03 exp94	-2.04
Oligomycin-A 20μM R00 exp26	-1.94
JQ1 0.8μM R08 exp435	-1.93
Colchicine 0.009μM R05 exp215	-1.75
CoCl2 18μM R07 exp346	-1.72
GSK461364A 0.1μM R03 exp126	-1.71
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.73
FBS-Wisent 0.1 R07 exp426	1.77
VHL-ligand-1 20μM R07 exp421	1.78
BI-6727 0.001μM R01 exp42	1.79
BS-181 20μM R08 exp461	1.79
GW501516 25μM R06 exp285	1.81
GSK461364A 0.005μM R03 exp125	1.93
S-trityl-L-cysteine 0.5μM R05 exp243	1.93
Ethambutol 25μM R08 exp481	1.95
Tozasertib 0.1μM R07 exp414	1.98
Taxol 0.004μM R03 exp103	2.06
BI-2536 0.0042μM R03 exp95	2.12
GSK591 2.6μM R03 exp128	2.12
OICR-9429 10μM R03 exp142	2.21
BH1 1μM R04 exp169	3.07

Global Fraction of Cell Lines Where Essential: 11/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	6/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 504
Expression level (log2 read counts): 8.38

Expression Distribution