Table of Contents

Momordin-Ic 10μM R08 exp506

Mechanism of Action

Triterpenoid saponin, putative SUMO-specific protease 1 (SENP1) inhibitor

Technical Notes

Compound References

  • PubChem Name: Momordin Ic
  • Synonyms: N/A
  • CAS #: 96990-18-0
  • PubChem CID: 176596
  • IUPAC: (2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-carboxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,5-dihydroxy-4-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxane-2-carboxylic acid
  • INCHI Name: InChI=1S/C41H64O13/c1-36(2)14-16-41(35(49)50)17-15-39(6)20(21(41)18-36)8-9-24-38(5)12-11-25(37(3,4)23(38)10-13-40(24,39)7)52-34-29(46)30(28(45)31(54-34)32(47)48)53-33-27(44)26(43)22(42)19-51-33/h8,21-31,33-34,42-46H,9-19H2,1-7H3,(H,47,48)(H,49,50)/t21-,22+,23-,24+,25-,26-,27+,28-,29+,30-,31-,33-,34+,38-,39+,40+,41-/m0/s1
  • INCHI Key: HWYBGIDROCYPOE-WEAQAMGWSA-N
  • Molecular Weight: 764.9
  • Canonical SMILES: CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)OC6C(C(C(C(O6)C(=O)O)O)OC7C(C(C(CO7)O)O)O)O)C)C)C2C1)C)C(=O)O)C
  • Isomeric SMILES: C[C@]12CC[C@@H](C([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)C)(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O[C@H]7[C@@H]([C@H]([C@@H](CO7)O)O)O)O
  • Molecular Formula: C41H64O13

Compound Supplier

  • Supplier Name: Toronto Research Chemicals
  • Catalog #: M638000
  • Lot #: 3-MJJ-12-1

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C41H64O13 787.42391; found 787.42417

Dose Response Curve

  • Platform ID: Momordin_Ic
  • Min: -1.9695; Max: 99.7054





IC Concentration (µM)
IC10 6.1700
IC20 8.2940
IC30 10.1000
IC40 11.8600
IC50 13.7500
IC60 15.9500
IC70 18.7300
IC80 22.8100
IC90 30.6600


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
11/1ScoresViewViewViewViewView