ATXN2L

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Actinomycin-D 0.001μM R00 exp3	-2.58
5-Fluorouracil 20μM R00 exp2	-2.5
Rapamycin 10μM R00 exp30	-2.39
Etoposide 10μM R00 exp20	-2.02
Torin1 0.08μM R02 exp82	-1.92
Rapamycin 1μM R00 exp29	-1.9
Trametinib 10μM R02 exp83	-1.86
MLN-4924 2μM R00 exp22	-1.83
Arsenate 40μM R06 exp264	-1.72
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.71
Lead acetate 2000μM R08 exp497	1.72
TRAIL 5ng/ml R00 exp35	1.74
GSK-J4 1-1.25μM to day4 R07 exp363	1.81
3-Bromopyruvate 7μM R04 exp175	1.86
Isoniazid 100μM R08 exp494	1.89
Artemisinin 50μM R08 exp450	1.9
All-trans-Retinoic-Acid 40μM R07 exp334	1.93
Hydroxyurea 100μM R07 exp329	2.07
Nicotinamide Riboside 100μM R03 exp139	2.11
Deferoxamine 11μM R07 exp350	2.23
TRAIL 50ng/ml R00 exp36	2.24
Diepoxybutane 3μM R07 exp354	2.37
Aminopterin 0.005μM R07 exp335	2.47
Olaparib 4μM R08 exp512	2.65
RK-33 8μM R08 exp518	2.86
2-Deoxy-D-glucose 800μM R05 exp214	4.1
Bortezomib 0.005μM R00 exp6	5.35

Gene	Correlation
LSM12	0.665
CDK6	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution