CDC25A
Gene Information
- Official Symbol: CDC25A
- Official Name: cell division cycle 25A
- Aliases and Previous Symbols: N/A
- Entrez ID: 993
- UniProt: P30304
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
Pfam Domains GO Terms
Pfam Domains
| Rhodanese |
| M-inducer phosp |
GO Terms
| regulation of G2/MI transition of meiotic cell cycle |
| positive regulation of G2/MI transition of meiotic cell cycle |
| positive regulation of meiotic cell cycle phase transition |
| regulation of meiotic cell cycle phase transition |
| positive regulation of meiotic cell cycle |
| positive regulation of G2/M transition of mitotic cell cycle |
| positive regulation of cell cycle G2/M phase transition |
| phosphoprotein phosphatase activity |
| regulation of meiotic cell cycle |
| positive regulation of mitotic cell cycle phase transition |
| positive regulation of reproductive process |
| cellular response to UV |
| positive regulation of cell cycle phase transition |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| protein tyrosine phosphatase activity |
| chaperone binding |
| regulation of cyclin-dependent protein kinase activity |
| peptidyl-tyrosine dephosphorylation |
| cellular response to light stimulus |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| G2/M transition of mitotic cell cycle |
| cell cycle G2/M phase transition |
| response to UV |
| positive regulation of mitotic cell cycle |
| regulation of reproductive process |
| cellular response to radiation |
| regulation of G2/M transition of mitotic cell cycle |
| regulation of cell cycle G2/M phase transition |
| protein dephosphorylation |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| protein deubiquitination |
| positive regulation of cell cycle process |
| protein modification by small protein removal |
| response to light stimulus |
| dephosphorylation |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| positive regulation of cell cycle |
| regulation of mitotic cell cycle phase transition |
| response to radiation |
| regulation of cell cycle phase transition |
| protein kinase binding |
| cell division |
| regulation of protein serine/threonine kinase activity |
| cell population proliferation |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| mitotic cell cycle |
| regulation of cell cycle process |
| regulation of protein kinase activity |
| regulation of kinase activity |
| regulation of transferase activity |
| protein modification by small protein conjugation or removal |
| cell cycle process |
| response to abiotic stimulus |
| regulation of cell cycle |
| proteolysis |
| cell cycle |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| TGF-beta1 44ng/ml R08 exp528 | -2.27 |
| Senexin-A 25μM R07 exp400 | -2.14 |
| Colchicine 0.009μM R05 exp215 | -1.98 |
| HMS-I1 1μM R01 exp46 | -1.87 |
| RO-3307 4.7μM R02 exp80 | -1.84 |
| Taxol 0.004μM R03 exp103 | -1.81 |
| BI-2536 0.0042μM R03 exp95 | -1.72 |
| Quercetin 20μM R08 exp517 | -1.7 |
| SGC0946 7μM R03 exp151 | -1.7 |
| Golgicide-A 2μM R03 exp121 | 1.71 |
| Wiskostatin 3μM R07 exp422 | 1.72 |
| Dynasore 10μM R04 exp180 | 1.83 |
| 42°C R08 exp539 | 1.88 |
| GSK626616 14μM R08 exp485 | 1.88 |
| GW501516 25μM R06 exp285 | 1.88 |
| Pterostilbene 16μM R02 exp78 | 2.52 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| CDK2 | 0.433 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 3/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2831
- Expression level (log2 read counts): 6.51
Expression Distribution
CDC25A Expression in NALM6 Cells: 6.51
