CDC37
Gene Information
- Official Symbol: CDC37
- Official Name: cell division cycle 37
- Aliases and Previous Symbols: N/A
- Entrez ID: 11140
- UniProt: Q16543
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). {ECO:0000269|PubMed:23569206, ECO:0000269|PubMed:8666233}.
Pfam Domains GO Terms
Pfam Domains
| CDC37 C |
| CDC37 M |
| CDC37 N |
GO Terms
| HSP90-CDC37 chaperone complex |
| positive regulation of mitophagy in response to mitochondrial depolarization |
| positive regulation of mitophagy |
| protein kinase regulator activity |
| chaperone complex |
| positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization |
| regulation of autophagy of mitochondrion in response to mitochondrial depolarization |
| regulation of mitophagy |
| response to mitochondrial depolarisation |
| positive regulation of autophagy of mitochondrion |
| regulation of interferon-gamma-mediated signaling pathway |
| regulation of response to interferon-gamma |
| ERBB2 signaling pathway |
| regulation of type I interferon-mediated signaling pathway |
| Hsp90 protein binding |
| regulation of autophagy of mitochondrion |
| heat shock protein binding |
| scaffold protein binding |
| positive regulation of macroautophagy |
| ERBB signaling pathway |
| kinase binding |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| chaperone binding |
| regulation of cyclin-dependent protein kinase activity |
| positive regulation of mitochondrion organization |
| positive regulation of autophagy |
| unfolded protein binding |
| regulation of cytokine-mediated signaling pathway |
| regulation of macroautophagy |
| regulation of response to cytokine stimulus |
| protein stabilization |
| regulation of mitochondrion organization |
| protein folding |
| regulation of protein stability |
| regulation of autophagy |
| protein targeting |
| positive regulation of cellular catabolic process |
| positive regulation of catabolic process |
| regulation of innate immune response |
| protein kinase binding |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of protein serine/threonine kinase activity |
| regulation of response to biotic stimulus |
| posttranscriptional regulation of gene expression |
| positive regulation of organelle organization |
| enzyme linked receptor protein signaling pathway |
| regulation of defense response |
| regulation of multi-organism process |
| regulation of protein kinase activity |
| regulation of cellular catabolic process |
| regulation of kinase activity |
| regulation of transferase activity |
| regulation of catabolic process |
| intracellular protein transport |
| regulation of response to external stimulus |
| regulation of immune response |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| regulation of protein phosphorylation |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of immune system process |
| cellular response to stress |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 528/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 23/28 |
| blood | 21/28 |
| bone | 18/26 |
| breast | 27/33 |
| central nervous system | 36/56 |
| cervix | 4/4 |
| colorectal | 15/17 |
| esophagus | 10/13 |
| fibroblast | 0/1 |
| gastric | 14/16 |
| kidney | 13/21 |
| liver | 13/20 |
| lung | 46/75 |
| lymphocyte | 11/16 |
| ovary | 18/26 |
| pancreas | 17/24 |
| peripheral nervous system | 12/16 |
| plasma cell | 10/15 |
| prostate | 1/1 |
| skin | 15/24 |
| soft tissue | 5/9 |
| thyroid | 0/2 |
| upper aerodigestive | 18/22 |
| urinary tract | 17/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 633
- Expression level (log2 read counts): 7.6
Expression Distribution
CDC37 Expression in NALM6 Cells: 7.6
