CEBPZ
Gene Information
- Official Symbol: CEBPZ
- Official Name: CCAAT enhancer binding protein zeta
- Aliases and Previous Symbols: N/A
- Entrez ID: 10153
- UniProt: Q03701
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. Methylation of the promoter of this gene or mutations within the gene may be correlated with occurance of acute myeloid leukemia (AML). [provided by RefSeq, Jun 2016].
- UniProt Summary: Stimulates transcription from the HSP70 promoter.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 116
- Expression level (log2 read counts): 6.55
CEBPZ Expression in NALM6 Cells: 6.55
