DICER1

Gene Information

Official Symbol: DICER1
Official Name: dicer 1, ribonuclease III
Aliases and Previous Symbols: N/A
Entrez ID: 23405
UniProt: Q9UPY3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010].
UniProt Summary: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. {ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:19219043}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.001μM R01 exp42	-2
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.89
Cyclosporin-A 0.8μM R07 exp347	-1.74
Tubastatin-A 2.5μM R07 exp417	-1.7
Benzoate 20000μM R08 exp456	1.8

Gene	Correlation
HARS	0.484
YARS	0.472
RTCB	0.47
THG1L	0.461
ADSL	0.437
MED16	0.435
GMPPB	0.434
HSPD1	0.434
PELO	0.427
RNMT	0.42
RPP21	0.417
RPTOR	0.416
EXOC4	0.415
NARS	0.411
WARS	0.411
EXOC3	0.411
ALG2	0.409
OIP5	0.408
ALG1	0.405
TELO2	0.405
SPCS3	0.404

Global Fraction of Cell Lines Where Essential: 89/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	2/28
blood	3/28
bone	3/26
breast	1/33
central nervous system	9/56
cervix	1/4
colorectal	1/17
esophagus	3/13
fibroblast	1/1
gastric	1/16
kidney	4/21
liver	3/20
lung	10/75
lymphocyte	1/16
ovary	2/26
pancreas	4/24
peripheral nervous system	6/16
plasma cell	3/15
prostate	0/1
skin	3/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	0/22
urinary tract	5/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 1975
Expression level (log2 read counts): 7.4

Expression Distribution