GPNMB
Gene Information
- Official Symbol: GPNMB
- Official Name: glycoprotein nmb
- Aliases and Previous Symbols: N/A
- Entrez ID: 10457
- UniProt: Q14956
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Could be a melanogenic enzyme. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| PKD |
GO Terms
| syndecan binding |
| melanosome membrane |
| positive regulation of protein autophosphorylation |
| receptor ligand activity |
| chemoattractant activity |
| regulation of protein autophosphorylation |
| bone mineralization |
| positive chemotaxis |
| negative regulation of tumor necrosis factor production |
| negative regulation of T cell proliferation |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| regulation of tissue remodeling |
| negative regulation of mononuclear cell proliferation |
| negative regulation of lymphocyte proliferation |
| negative regulation of leukocyte proliferation |
| biomineralization |
| biomineral tissue development |
| negative regulation of G1/S transition of mitotic cell cycle |
| negative regulation of cell cycle G1/S phase transition |
| negative regulation of T cell activation |
| negative regulation of leukocyte cell-cell adhesion |
| osteoblast differentiation |
| integrin binding |
| negative regulation of lymphocyte activation |
| regulation of tumor necrosis factor production |
| regulation of G1/S transition of mitotic cell cycle |
| regulation of tumor necrosis factor superfamily cytokine production |
| early endosome membrane |
| regulation of T cell proliferation |
| regulation of cell cycle G1/S phase transition |
| heparin binding |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| negative regulation of cell activation |
| negative regulation of neuron death |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of ERK1 and ERK2 cascade |
| negative regulation of mitotic cell cycle phase transition |
| regulation of leukocyte proliferation |
| negative regulation of cell cycle phase transition |
| ossification |
| negative regulation of cell adhesion |
| negative regulation of cytokine production |
| regulation of angiogenesis |
| regulation of ERK1 and ERK2 cascade |
| regulation of leukocyte cell-cell adhesion |
| negative regulation of mitotic cell cycle |
| regulation of neuron death |
| regulation of T cell activation |
| regulation of vasculature development |
| negative regulation of cell cycle process |
| regulation of cell-cell adhesion |
| regulation of mitotic cell cycle phase transition |
| negative regulation of immune system process |
| regulation of cell cycle phase transition |
| positive regulation of cell migration |
| regulation of lymphocyte activation |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| chemotaxis |
| positive regulation of locomotion |
| taxis |
| negative regulation of cell cycle |
| regulation of leukocyte activation |
| regulation of mitotic cell cycle |
| regulation of cell activation |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| regulation of cytokine production |
| regulation of MAPK cascade |
| regulation of cell cycle process |
| regulation of cell migration |
| regulation of cell motility |
| cell adhesion |
| biological adhesion |
| regulation of locomotion |
| negative regulation of cell death |
| regulation of cellular component movement |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell-cell signaling |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| locomotion |
| integral component of plasma membrane |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.425 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11173
- Expression level (log2 read counts): 1.93
Expression Distribution
GPNMB Expression in NALM6 Cells: 1.93
