GPR75-ASB3

Entrez Summary: N/A
UniProt Summary: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B. {ECO:0000269|PubMed:15899873}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-2.51
Rapamycin 1μM R00 exp29	-2.37
Rapamycin 0.001μM R08 exp429	-2.29
Dexamethasone 0.006μM R07 exp351	-2.28
Tunicamycin 0.04μM R07 exp418	-2.23
Rifampicin 30μM R08 exp430	-2.22
CyclicAMP 200μM R08 exp475	-2.17
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-2.16
Wortmannin 5μM R00 exp38	-2.16
UM131593 0.2μM R03 exp106	-2.15
Demecolcine 0.03μM R05 exp228	-2.01
Bortezomib 0.005μM R00 exp6	-2
BML-284 0.09μM R08 exp460	-1.99
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.98
Wortmannin 0.5μM R00 exp37	-1.97
Rifampicin 1μM R00 exp31	-1.95
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.9
A-769662 20μM R07 exp331	-1.87
YM155 0.001μM R08 exp432	-1.81
Genistein 15μM R07 exp360	-1.78
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.73
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.72
BI-2536 0.0042μM R03 exp95	2.24

Expression Distribution