IPO9

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.62
Ribavirin 10μM R01 exp52	-2.44
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-2.16
UM131593 0.1μM R01 exp58	-2.15
HMS-I1 1μM R01 exp46	-2.03
IU1-47 25μM R04 exp182	-2.02
Mdivi-1 15μM R05 exp217	-1.89
Methotrexate 0.01μM R08 exp501	-1.88
2-Methoxyestradiol 0.55μM R07 exp310	-1.86
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.86
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.81
Aphidicolin 0.04μM R06 exp263	-1.79
UMK57 1μM R01 exp59	-1.79
Dimethyloxaloylglycine 11μM R07 exp314	-1.78
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.72
CoCl2 18μM R07 exp346	-1.7
KU-0063794 3.8μM R02 exp71	2.55
MK2206 4μM R08 exp504	2.74

Gene	Correlation
ELMSAN1	0.408
RPP21	0.407

Global Fraction of Cell Lines Where Essential: 367/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	12/28
blood	13/28
bone	9/25
breast	20/33
central nervous system	23/56
cervix	1/4
colorectal	7/17
esophagus	7/13
fibroblast	1/1
gastric	10/15
kidney	14/21
liver	9/20
lung	41/75
lymphocyte	5/14
ovary	15/26
pancreas	19/24
peripheral nervous system	3/16
plasma cell	10/15
prostate	0/1
skin	18/24
soft tissue	1/7
thyroid	2/2
upper aerodigestive	14/22
urinary tract	19/29
uterus	1/5

Expression Distribution