MIOS

Gene Information

Official Symbol: MIOS
Official Name: meiosis regulator for oocyte development
Aliases and Previous Symbols: N/A
Entrez ID: 54468
UniProt: Q9NXC5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:27487210}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rifampicin 1μM R00 exp31	-2.11
PF-06409577 20μM R07 exp389	-1.76
Aphidicolin 0.04μM R06 exp263	-1.73
Q15 2.7μM R02 exp79	1.72
Sulforaphane 9μM R08 exp525	1.72
Tubacin 1.6μM R07 exp416	1.73
Dimethyl-Sulfoxide 1pc R03 exp120	1.75
Nocodazole 0.2μM R02 exp64	1.78
CR131-b 0.005μM R08 exp474	1.8
RO-3307 4.7μM R02 exp80	1.84
Artemisinin 50μM R08 exp450	1.89
Atovaquone 15μM R08 exp451	1.89
Menadione 5μM R06 exp292	1.92
Bortezomib 0.05μM R00 exp7	1.95
AICAR 240μM R03 exp116	1.98
Rotenone 20μM R00 exp34	2
Radicicol 0.16μM R05 exp242	2.02
GSK461364A 0.1μM R03 exp126	2.06
JQ1 0.8μM R08 exp435	2.08
AICAR 240μM R05 exp211	2.18
Nocodazole 0.1μM R03 exp94	2.18
Rotenone 2μM R00 exp33	2.27
CB-5083 0.4μM R08 exp468	2.28
LY2090314 0.003μM R08 exp499	2.28
UM131593 0.2μM R03 exp106	2.34
DABN racemic mixture R03 exp93	2.39
LY2090314 0.003μM R08 exp500 no dilution day6	2.52
TRAIL 50ng/ml R00 exp36	2.8
MLN-4924 0.2μM R00 exp21	2.85
3-Bromopyruvate 7μM R04 exp175	3.12
5-Fluorouracil 20μM R00 exp2	3.28
Actinomycin-D 0.001μM R00 exp3	3.92

Gene	Correlation
WDR24	0.693
LAMTOR2	0.607
RPTOR	0.599
WDR59	0.591
FNIP1	0.564
LAMTOR4	0.553
MTOR	0.533
MEAF6	0.518
LAMTOR5	0.495
FLCN	0.483
TBC1D5	0.479
TBP	0.475
HARS	0.469
LAMTOR1	0.466
RRAGA	0.463
EIF4E	0.455
DOHH	0.447
MLST8	0.446
FBXO11	0.437
THOC6	0.429
VPS41	0.425
ZNF592	0.423
VDAC2	0.422
SLC7A5	0.419
SERF2	0.416
BAK1	0.415
EIF4G1	0.413
ID3	0.411
ENY2	0.409
CYCS	0.409
MLLT1	0.408
MARCH5	0.406
DIABLO	0.4

Global Fraction of Cell Lines Where Essential: 64/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	4/28
blood	7/28
bone	2/26
breast	2/33
central nervous system	3/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	3/21
liver	0/20
lung	7/75
lymphocyte	4/16
ovary	2/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	5/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	4/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1723
Expression level (log2 read counts): 6.04

Expression Distribution