NUP88
Gene Information
- Official Symbol: NUP88
- Official Name: nucleoporin 88
- Aliases and Previous Symbols: N/A
- Entrez ID: 4927
- UniProt: Q99567
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Essential component of nuclear pore complex.
Pfam Domains GO Terms
Pfam Domains
| Nup88 |
GO Terms
| ribosomal small subunit export from nucleus |
| ribosomal large subunit export from nucleus |
| ribosome localization |
| ribosomal subunit export from nucleus |
| rRNA-containing ribonucleoprotein complex export from nucleus |
| structural constituent of nuclear pore |
| tRNA-containing ribonucleoprotein complex export from nucleus |
| tRNA export from nucleus |
| tRNA transport |
| ncRNA export from nucleus |
| transporter activity |
| intracellular transport of virus |
| host cell |
| transport of virus |
| protein sumoylation |
| multi-organism transport |
| multi-organism localization |
| nuclear pore |
| regulation of cellular response to heat |
| regulation of glycolytic process |
| regulation of gene silencing by miRNA |
| regulation of carbohydrate catabolic process |
| regulation of gene silencing by RNA |
| regulation of posttranscriptional gene silencing |
| protein import into nucleus |
| mRNA export from nucleus |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| viral transcription |
| import into nucleus |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| viral gene expression |
| regulation of gene silencing |
| protein import |
| protein export from nucleus |
| mRNA transport |
| regulation of generation of precursor metabolites and energy |
| nuclear export |
| protein localization to nucleus |
| nucleic acid transport |
| RNA transport |
| establishment of RNA localization |
| viral life cycle |
| regulation of carbohydrate metabolic process |
| RNA localization |
| nucleobase-containing compound transport |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| nuclear transport |
| ribosome biogenesis |
| peptidyl-lysine modification |
| establishment of organelle localization |
| regulation of small molecule metabolic process |
| establishment of protein localization to organelle |
| ribonucleoprotein complex biogenesis |
| organelle localization |
| mitotic cell cycle |
| viral process |
| regulation of cellular response to stress |
| protein localization to organelle |
| protein modification by small protein conjugation |
| symbiotic process |
| interspecies interaction between organisms |
| peptidyl-amino acid modification |
| protein modification by small protein conjugation or removal |
| intracellular protein transport |
| regulation of catabolic process |
| cell cycle |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 425/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 21/28 |
| blood | 21/28 |
| bone | 15/26 |
| breast | 25/33 |
| central nervous system | 23/56 |
| cervix | 1/4 |
| colorectal | 12/17 |
| esophagus | 9/13 |
| fibroblast | 1/1 |
| gastric | 8/16 |
| kidney | 10/21 |
| liver | 16/20 |
| lung | 38/75 |
| lymphocyte | 8/16 |
| ovary | 19/26 |
| pancreas | 17/24 |
| peripheral nervous system | 6/16 |
| plasma cell | 11/15 |
| prostate | 1/1 |
| skin | 15/24 |
| soft tissue | 7/9 |
| thyroid | 0/2 |
| upper aerodigestive | 9/22 |
| urinary tract | 20/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 1074
- Expression level (log2 read counts): 6.83
Expression Distribution
NUP88 Expression in NALM6 Cells: 6.83
