NUP98
Gene Information
- Official Symbol: NUP98
- Official Name: nucleoporin 98 and 96 precursor
- Aliases and Previous Symbols: N/A
- Entrez ID: 4928
- UniProt: P52948
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Nup96 |
| Nucleoporin2 |
GO Terms
| posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery |
| nuclear pore cytoplasmic filaments |
| telomere tethering at nuclear periphery |
| transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery |
| nuclear pore complex assembly |
| nuclear pore outer ring |
| nuclear pore nuclear basket |
| nuclear inclusion body |
| telomere localization |
| nuclear periphery |
| nuclear pore organization |
| pore complex assembly |
| positive regulation of mRNA splicing, via spliceosome |
| nuclear localization sequence binding |
| structural constituent of nuclear pore |
| positive regulation of mRNA processing |
| tRNA-containing ribonucleoprotein complex export from nucleus |
| tRNA export from nucleus |
| positive regulation of RNA splicing |
| tRNA transport |
| ncRNA export from nucleus |
| transporter activity |
| promoter-specific chromatin binding |
| intracellular transport of virus |
| host cell |
| transport of virus |
| serine-type peptidase activity |
| protein sumoylation |
| multi-organism transport |
| multi-organism localization |
| nuclear pore |
| chromosome localization |
| positive regulation of mRNA metabolic process |
| regulation of cellular response to heat |
| regulation of glycolytic process |
| kinetochore |
| regulation of gene silencing by miRNA |
| regulation of carbohydrate catabolic process |
| regulation of posttranscriptional gene silencing |
| regulation of gene silencing by RNA |
| protein import into nucleus |
| regulation of mRNA splicing, via spliceosome |
| mRNA export from nucleus |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| viral transcription |
| import into nucleus |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| viral gene expression |
| regulation of gene silencing |
| nucleus organization |
| regulation of RNA splicing |
| regulation of mRNA processing |
| protein import |
| protein export from nucleus |
| mRNA transport |
| ribonucleoprotein complex |
| regulation of generation of precursor metabolites and energy |
| nuclear export |
| mRNA binding |
| protein localization to nucleus |
| nuclear envelope |
| nucleic acid transport |
| RNA transport |
| establishment of RNA localization |
| viral life cycle |
| regulation of carbohydrate metabolic process |
| DNA replication |
| RNA localization |
| nuclear membrane |
| nucleobase-containing compound transport |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| nuclear transport |
| nuclear body |
| transcription coactivator activity |
| peptidyl-lysine modification |
| regulation of mRNA metabolic process |
| regulation of small molecule metabolic process |
| establishment of protein localization to organelle |
| organelle localization |
| intracellular membrane-bounded organelle |
| viral process |
| regulation of cellular response to stress |
| protein localization to organelle |
| protein modification by small protein conjugation |
| symbiotic process |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| peptidyl-amino acid modification |
| protein modification by small protein conjugation or removal |
| intracellular protein transport |
| regulation of catabolic process |
| chromosome organization |
| proteolysis |
| RNA binding |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 237/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 10/28 |
| blood | 9/28 |
| bone | 7/26 |
| breast | 16/33 |
| central nervous system | 16/56 |
| cervix | 0/4 |
| colorectal | 2/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 5/16 |
| kidney | 6/21 |
| liver | 8/20 |
| lung | 19/75 |
| lymphocyte | 8/16 |
| ovary | 14/26 |
| pancreas | 10/24 |
| peripheral nervous system | 7/16 |
| plasma cell | 10/15 |
| prostate | 1/1 |
| skin | 7/24 |
| soft tissue | 3/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 11/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1871
- Expression level (log2 read counts): 7.58
Expression Distribution
NUP98 Expression in NALM6 Cells: 7.58
