RABGEF1
Gene Information
- Official Symbol: RABGEF1
- Official Name: RAB guanine nucleotide exchange factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 27342
- UniProt: Q9UJ41
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity). {ECO:0000250, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:15339665, ECO:0000269|PubMed:9323142}.
Pfam Domains GO Terms
Pfam Domains
| zf-A20 |
| VPS9 |
GO Terms
| negative regulation of Kit signaling pathway |
| regulation of Kit signaling pathway |
| negative regulation of mast cell degranulation |
| negative regulation of mast cell activation involved in immune response |
| negative regulation of myeloid leukocyte mediated immunity |
| negative regulation of interleukin-6 secretion |
| regulation of Fc receptor mediated stimulatory signaling pathway |
| negative regulation of leukocyte degranulation |
| negative regulation of mast cell activation |
| negative regulation of receptor-mediated endocytosis |
| negative regulation of regulated secretory pathway |
| negative regulation of exocytosis |
| regulation of mast cell degranulation |
| regulation of mast cell activation involved in immune response |
| Rab guanyl-nucleotide exchange factor activity |
| negative regulation of interleukin-6 production |
| negative regulation of endocytosis |
| regulation of mast cell activation |
| negative regulation of leukocyte migration |
| negative regulation of leukocyte mediated immunity |
| regulation of leukocyte degranulation |
| negative regulation of Ras protein signal transduction |
| regulation of myeloid leukocyte mediated immunity |
| negative regulation of small GTPase mediated signal transduction |
| negative regulation of intracellular transport |
| negative regulation of cytokine-mediated signaling pathway |
| negative regulation of response to cytokine stimulus |
| negative regulation of cytokine secretion |
| regulation of receptor-mediated endocytosis |
| recycling endosome |
| negative regulation of immune effector process |
| negative regulation of protein secretion |
| negative regulation of inflammatory response |
| negative regulation of peptide secretion |
| regulation of interleukin-6 production |
| negative regulation of immune response |
| Rab GTPase binding |
| early endosome membrane |
| protein targeting to membrane |
| regulation of cytokine-mediated signaling pathway |
| regulation of regulated secretory pathway |
| negative regulation of leukocyte activation |
| regulation of response to cytokine stimulus |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| regulation of leukocyte migration |
| negative regulation of cell activation |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of endocytosis |
| regulation of leukocyte mediated immunity |
| negative regulation of defense response |
| positive regulation of immune effector process |
| ubiquitin protein ligase activity |
| regulation of exocytosis |
| negative regulation of secretion |
| regulation of Ras protein signal transduction |
| early endosome |
| negative regulation of cell migration |
| establishment of protein localization to membrane |
| negative regulation of cytokine production |
| negative regulation of cell motility |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| regulation of inflammatory response |
| regulation of small GTPase mediated signal transduction |
| regulation of intracellular transport |
| protein targeting |
| negative regulation of response to external stimulus |
| negative regulation of protein phosphorylation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of protein secretion |
| regulation of immune effector process |
| protein localization to membrane |
| negative regulation of transport |
| regulation of peptide secretion |
| negative regulation of intracellular signal transduction |
| regulation of vesicle-mediated transport |
| endocytosis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| regulation of leukocyte activation |
| regulation of cell activation |
| import into cell |
| protein ubiquitination |
| regulation of cytokine production |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| protein modification by small protein conjugation |
| regulation of secretion |
| zinc ion binding |
| regulation of cell migration |
| nucleolus |
| regulation of cell motility |
| regulation of cellular localization |
| regulation of locomotion |
| protein modification by small protein conjugation or removal |
| intracellular protein transport |
| regulation of cellular component movement |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| DNA binding |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| regulation of transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| AAGAB | 0.411 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6975
- Expression level (log2 read counts): 5.18
Expression Distribution
RABGEF1 Expression in NALM6 Cells: 5.18
