RANGAP1
Gene Information
- Official Symbol: RANGAP1
- Official Name: Ran GTPase activating protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5905
- UniProt: P46060
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
Pfam Domains GO Terms
Pfam Domains
| RanGAP1 C |
GO Terms
| cytoplasmic periphery of the nuclear pore complex |
| response to vasopressin |
| cellular response to vasopressin |
| nuclear pore cytoplasmic filaments |
| negative regulation of protein export from nucleus |
| negative regulation of nucleocytoplasmic transport |
| maintenance of protein location in nucleus |
| Ran GTPase binding |
| regulation of protein export from nucleus |
| maintenance of protein localization in organelle |
| negative regulation of intracellular protein transport |
| aggresome |
| response to axon injury |
| axon cytoplasm |
| negative regulation of intracellular transport |
| protein sumoylation |
| nuclear pore |
| maintenance of protein location in cell |
| mitotic spindle |
| kinetochore |
| condensed chromosome kinetochore |
| maintenance of location in cell |
| activation of GTPase activity |
| regulation of nucleocytoplasmic transport |
| maintenance of protein location |
| negative regulation of cellular protein localization |
| protein localization to nucleus |
| maintenance of location |
| nuclear envelope |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| regulation of intracellular protein transport |
| nuclear membrane |
| cellular response to peptide hormone stimulus |
| GTPase activator activity |
| ubiquitin protein ligase binding |
| cadherin binding |
| peptidyl-lysine modification |
| cellular response to peptide |
| regulation of intracellular transport |
| response to peptide hormone |
| positive regulation of GTPase activity |
| dendrite |
| response to peptide |
| regulation of GTPase activity |
| negative regulation of transport |
| regulation of cellular protein localization |
| response to wounding |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| intracellular membrane-bounded organelle |
| perinuclear region of cytoplasm |
| regulation of protein transport |
| protein localization to organelle |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| positive regulation of hydrolase activity |
| protein modification by small protein conjugation |
| peptidyl-amino acid modification |
| response to hormone |
| regulation of cellular localization |
| protein modification by small protein conjugation or removal |
| response to organonitrogen compound |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| cellular response to endogenous stimulus |
| regulation of hydrolase activity |
| RNA binding |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of molecular function |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 450/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 22/28 |
| blood | 21/28 |
| bone | 13/26 |
| breast | 23/33 |
| central nervous system | 35/56 |
| cervix | 3/4 |
| colorectal | 12/17 |
| esophagus | 8/13 |
| fibroblast | 1/1 |
| gastric | 11/16 |
| kidney | 8/21 |
| liver | 11/20 |
| lung | 52/75 |
| lymphocyte | 14/16 |
| ovary | 15/26 |
| pancreas | 18/24 |
| peripheral nervous system | 5/16 |
| plasma cell | 12/15 |
| prostate | 1/1 |
| skin | 15/24 |
| soft tissue | 5/9 |
| thyroid | 1/2 |
| upper aerodigestive | 9/22 |
| urinary tract | 16/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 664
- Expression level (log2 read counts): 7.57
Expression Distribution
RANGAP1 Expression in NALM6 Cells: 7.57
